ANCESTRY, ADMIXTURE, AND HEALTH DISPARITIES

My interest in the concept of “racial admixture” goes well beyond the personal. The concept has become important in health disparities research.

CLINICAL TRIALS

A search of the clinical trials database http://www.clinicaltrials.gov, using the phrase “racial admixture,” returned four results.

  • Admixture Mapping of Ethnic and Racial Insulin Complex Outcomes
  • Racial and Genetic Biomarkers of Response in Tissue Samples From Patients With Endometrial Cancer
  • Bad Genes or Genes Behaving Badly
  • Puberty Related Intervention to Improve Metabolic Outcomes (The PRIMO Study)

 

NATIONAL INSTITUTES OF HEALTH

 

A search of the National Institutes of Health Project Database using the same search term produced 41 results.

https://projectreporter.nih.gov/reporter.cfm

One of the projects most interesting to me is being conducted at Virginia Commonwealth University. One hypothesis being tested in this research is that both African ancestry and the admixture of European ancestry make a contribution to the preterm premature rupture of membranes that plays an important role in the higher rate of premature births among African American women.
https://projectreporter.nih.gov/project_info_description.cfm?aid=8906535&icde=29258566&ddparam=&ddvalue=&ddsub=&cr=29&csb=default&cs=ASC

 

VITAMIN D
A very different approach to the prevention of preterm births is supported by vitamin D researchers.

This week I am so honored to announce a new paper that clearly shows the >50% reduction in risk of preterm birth with a vitamin D serum level of at least 40 ng/mL from a randomized controlled trial done by Hollis and Wagner.
http://archive.constantcontact.com/fs187/1102722411090/archive/1122775944928.html

 

Medical University of South Carolina Leads the Way

EVERY new prenatal patient at the Medical University of South Carolina (MUSC) will now be screened for vitamin D deficiency, and, they will have recommended supplementation to get their 25(OH)D serum levels to at least 40 ng/ml as part of the GrassrootsHealth Protect our Children NOW! Project.
http://archive.constantcontact.com/fs187/1102722411090/archive/1122195152911.html

 

 

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